Two sample MR report
THBS1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.1172761 | 1.1237801 | 0.9264074 |
| Weighted median | 4 | -0.1705354 | 0.0827795 | 0.0393875 |
| Inverse variance weighted | 4 | -0.1742504 | 0.0749638 | 0.0201009 |
| Simple mode | 4 | -0.1680850 | 0.1158796 | 0.2428038 |
| Weighted mode | 4 | -0.1675804 | 0.1126659 | 0.2336276 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0736964 | 2 | 0.9638224 |
| Inverse variance weighted | 0.0762783 | 3 | 0.9945235 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0136639 | 0.2689109 | 0.9640937 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 6.8e-05 | 0 | TRUE | 0.4337384 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
